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α-Cyclodextrin (α-CD) CAS 10016-20-3 Pharmaceutical Excipients Featured Image
  • α-Cyclodextrin (α-CD) CAS 10016-20-3 Pharmaceutical Excipients
  • α-Cyclodextrin (α-CD) CAS 10016-20-3 Pharmaceutical Excipients
  • α-Cyclodextrin (α-CD) CAS 10016-20-3 Pharmaceutical Excipients

α-Cyclodextrin (α-CD) CAS 10016-20-3 Pharmaceutical Excipients

Short Description:

Chemical Name: α-Cyclodextrin

Synonyms: α-CD; alpha-Cyclodextrin 

CAS: 10016-20-3

Assay: 98.0%~101.0% 

White or Almost White Amorphous or Crystalline Powder

Pharmaceutical Excipients, High Quality 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Product Detail

Related Products

Product Tags

Pharma Grade Cyclodextrins:

β-Cyclodextrin  β-CD CAS 7585-39-9
α-Cyclodextrin  α-CD CAS 10016-20-3
γ-Cyclodextrin  γ-CD CAS 17465-86-0
Betadex Sulfobutyl Ether Sodium  SBE-β-CD            CAS 182410-00-0  
Hydroxypropyl-β-Cyclodextrin  HP-β-CD CAS 128446-35-5               
Carboxymethyl-β-Cyclodextrin  CM-β-CD CAS 218269-34-2
Methyl-β-Cyclodextrin  Me-β-CD CAS 128446-36-6
(2-Hydroxypropyl)-γ-Cyclodextrin  HP-γ-CD CAS 128446-34-4

10016-20-3 - Description:

Ruifu Chemical is the leading manufacturer of α-Cyclodextrin (α-CD) (CAS: 10016-20-3) with high quality. Ruifu Chemical supplies pharma grade cyclodextrins, pharmaceutical excipients. Ruifu Chemical can provide worldwide delivery, small and bulk quantities available. Purchase α-Cyclodextrin, Please contact: alvin@ruifuchem.com

10016-20-3 - Chemical Properties:

Chemical Name α-Cyclodextrin 
Synonyms α-CD; C; Alfadex; alpha-Dextrin; α-Dextrin; Cyclohexapentylose; Cavamax W6; Schardinger α-Dextrin; α-Schardinger Dextrin; Schardinger alpha-Dextrin; Cyclomaltohexaose; Cyclohexaamylose
Stock Status In Stock, Commercial Production  
CAS Number 10016-20-3
Molecular Formula C36H60O30
Molecular Weight 972.84 g/mol
Melting Point >278℃(dec.) (lit.)
Density 1.483 g/cm3 at 20℃
Water Solubility  Soluble in Water 
Stability  Stable. Combustible. Incompatible With Strong Oxidizing Agents.
COA & MSDS Available
Free Sample  Available
Origin Shanghai, China
Category   Pharmaceutical Excipients; Food Additives 
Shelf Life 36 Months if Stored Properly
Brand Ruifu Chemical

10016-20-3 - Specifications:

Items           Specifications Results
Appearance White or Almost White Amorphous or Crystalline Powder  Conforms
Solubility  Freely Soluble in Water and in Propylene Glycol, Practically Insoluble in Ethanol and in Methylene Chloride Conforms
ldentification HPLC  The retention time of the major peak of sample solution corresponds to the standard solution. Conforms
Iodine Test Solution A Yellow-Brown Precipitate is Formed Conforms
Assay 98.0%~101.0% (Calculated on the Dried Basis) 100.0%
Specific Rotation [a]20/D  +147.0° to +152.0°(C=1 in H2O) (Calcd. on Anh. Substance)  +148.2°
Clarity & Color of Solution  10mg/ml Water Solution is Clear and Colorless  Conforms
Limit of Light-Absorbing Substances  ≤0.10 (230 nm~350 nm) ≤0.05 (350 nm~750 nm) Conforms
Water Determination  ≤11.0% 9.9%
Residue on Ignition ≤0.10% 0.07%
Heavy Metals ≤5ppm <5ppm
Arsenic Salt (As) ≤1.3ppm <1.3ppm
Reducing Sugars   ≤0.20% 0.16%
Related Substances    
Betadex Cyclodextrin   ≤0.25% N/D 
Gamma Cyclodextrin ≤0.25% N/D  
Other Related Substances  ≤0.50%  N/D  
pH  5.0~8.0 6.2
Microbiological Test    
Total Aerobic Microbial Counts                          ≤1000cfu/g 30cfu/g 
Total Molds & Yeasts Counts ≤50cfu/g <50cfu/g
Escherichia Coli Absent  Absent
Salmonella Absent Absent
Infrared Spectrum Conforms to Structure Conforms
Test Standard  USP41-NF36 

Package/Storage/Shipping:

Package: 0.5kg//bag, 1kg/bag, 2kg/bag,10kg/bag, 25kg/Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture. Incompatible with strong oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

10016-20-3 - Safety Information:

Hazard Symbols Xi - Irritant
Risk Codes R36 - Irritating to the eyes
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany 3
RTECS GU2292000
TSCA Yes
HS Code 3505100000

10016-20-3 - Product Introduction:

α-Cyclodextrin (α-CD) (CAS: 10016-20-3) is a non-reducing cyclic saccharide comprised of six glucose units linked by alpha-1.4 bonds. It is produced by the action of cyclodextrin glucosyl transferase on hydrolysed starch syrups. The cavity of α-Cyclodextrin is less than beta-Cyclodextrin, so it is used to allow formation of inclusion complexes with little molecules. The solubility degree of α-Cyclodextrin in water is 14.5 g/100ml @25℃, so the situation that needs high solubility of cyclodextrin.
α-Cyclodextrin is widely used in the drugs, food, flavor and cosmetics. α-Cyclodextrin is also widely used in the field of pesticide and adjusting the metabolization of the crop and increasing the quantity of the crop. Especially the cyclodextrin and its ramification which developed by these years, some of them are the important solutizer, stablizer, releaser or the assist materials of the Entericcoated drugs,some of them are the materials of organic synthetical macromolecular stuff.
Food grade α-Cyclodextrin with 6 glucose units has the smallest cavity of the parent cyclodextrins. It is useful for solubilizing,stabilizing or delivering small molecules, e.g. low molecular weight, flavor or fragrance compounds. Food grade α-Cyclodextrin is being introduced to the food industry as a new soluble dietary fiber with convincing properties. 

10016-20-3 - Application:

Cyclodextrin has a hole in the center of the ring structure, and an oxygen atom in which -CH- binds to glucoside. It is sulfur-aqueous, and the hydroxyl groups at the 2, 3 and 6 positions of glucose are hydrophilic. It can be used to complex other molecules into inclusion complexes by a weak van der Waals force. Many substances can be encapsulated by cyclodextrins, including noble gases, halogens, dyes, fragrances, medicines, foods, pesticides and preservatives. After encapsulation, its stability, volatility, solubility and reactivity are improved. The special effect of Cyclodextrin makes it a widely used encapsulation material.
1. The use of Cyclodextrin in the pharmaceutical industry can form encapsulation (encapsulation) with drugs, which can make (1) Unstable drugs stable; (2) Deliquescence, adhesion or liquid drug powderization; (3) Insoluble or insoluble drugs can be dissolved (solubilized), etc.
2. Use in pesticide industry cyclodextrin encapsulation stabilization, some pesticides can be stored and improve insecticidal efficacy.
3. Uses in the food industry cyclodextrin is used in the food industry, has the following effects: (1) Elimination and cover up the special odor; (2) The improvement and improvement of food tissue structure; (3) the alleviation and removal of bitter taste; (4) Antioxidant effect; (5) Preservation and optimization of flavor.
4. The use of Cyclodextrin in the daily chemical industry in cosmetic manufacturing can also be used as emulsifier and quality improver. It also has deodorization (such as in addition to halitosis) and antiseptic effects, can be used for toothpaste, tooth powder manufacturing.
5. Other uses in environmental protection can be used as a treatment agent of oily sewage. The aqueous solution of Cyclodextrin is used to clean the oil tank, and the waste liquid can be recovered and treated to obtain fuel oil.
6. The use of cyclodextrin in chemistry Cyclodextrin is a valuable chemical reagent. When it is present, the fluorescence intensity of fluorochrome will increase significantly, so it can be used for the analysis of proteins and amino acids. It can also be used to separate long chain organic compounds, racemes, etc.
In addition, the adsorbent made from Cyclodextrin can be used for chromatographic adsorption.

10016-20-3 - Function and Application:

Function
1. α-Cyclodextrin Increase the stability of the material: Prevent volatilization, prevent sublimation; Anti-oxidation; Prevent optothermal decomposition; Anti chemical decomposition; Extend the period of validity of the material.
2. α-Cyclodextrin Increase the material solubility and bioavailability.
3. α-Cyclodextrin through the formation of inclusion complex to achieve effective cover excitant odour.
4. α-Cyclodextrin Liquid drug into solid state.
5. α-Cyclodextrin To prevent drug - drug, drug - interaction between additive.
6. α-Cyclodextrin Reduce side effects.
Application
1. α-Cyclodextrin is used to increase the stability of the material:Prevent volatilization, prevent sublimation; Anti-oxidation;
2. α-Cyclodextrin is used to prevent optothermal decomposition; Anti chemical decomposition; Extend the period of validity of the material.
3. α-Cyclodextrin is used to increase the material solubility and bioavailability.
4. Through the formation of inclusion complex to achieve effective cover excitant odour. Liquid drug into solid state.
5. α-Cyclodextrin is used to prevent drug - drug, drug - interaction between additive.
6. α-Cyclodextrin is used to reduce side effects.

10016-20-3 - Application Areas:

Pharmaceutical:
1. To increase the solubility of biological availability
2. To improve the bioavailability
3. To adjust or control the releasing
4. To decrease the toxicities
5. To improve the stabilities
Cosmetic:
1. To suit for encapsulation of volatile compounds.
2. To increase shelf life of expensive flavours.
Food:
1.To prevent evaporation of volatile substances.
2.To get rid of the terrible smell.
3.To significantly enhance the effects of emulsification 

10016-20-3 - Biochem / Physiol Actions:

α-Cyclodextrin is found to form a firm complex with dietary fats. This way it decreases the bioavailability and absorption of fats. It is known to regulate triglyceride and leptin levels in serum. In rat models, α-Cyclodextrin is shown to induce insulin sensitivity and fecal fat excretion. Thus, α-Cyclodextrin is considered to be effective for treating obesity and metabolic syndromes.

10016-20-3 - Regulatory Status:

Included in the FDA Inactive Ingredients Database: α-Cyclodextrin (injection preparations); β-Cyclodextrin (oral tablets, topical gels); γ-Cyclodextrin (IV injections). Included in the Canadian List of Acceptable Non-medicinal Ingredients (stabilizing agent; solubilizing agent ); and in oral and rectal pharmaceutical formulations licensed in Europe, Japan, and the USA.   

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